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Erection and flaccidity of the penis is a vascular phenomenon. The penile erectile tissue or the corpora cavernosa plays a key role in the erectile process. Sexual stimulation triggers the release of chemicals which cause relaxation of smooth muscles. This increases blood flow in the arteries and the smaller arterioles. The incoming blood is trapped by the vascular spaces. The venous outflow is reduced by compression of the veins. The partial pressure of oxygen in the blood rises from 35 to 90mm/hg and the pressure in the cavernosa climbs to 100mm/hg which erects the penis. A rigid erection occurs with further contraction of the pelvic floor muscles. The rigid penis becomes flaccid with a slow opening of the venous channels and then a fast pressure decrease with a fully restored venous outflow.

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Muira Puama – Is derived from the bark of a tree or its roots. This small tree is native to the Amazonian region of South America and has a plethora of uses among the indigenous peoples of the Amazon, including the following: adaptogen, alopecia (applied topically for hair loss), anorexia, antinociceptive, antioxidant, aphrodisiac, ataxia, beri beri (vitamin deficiency disease), debility, digestive problems, dysentery, fatigue, impotence, neurasthenia, nerve tonic, rheumatism, stimulant, tonic (adding bark decoction to a bath), paralysis, and tremors (Quattrocchi, 2012; Piato et al., 2010; Berdonces, 2009; Duke et al., 2009; Taylor, 2005; Rutter, 1990). Muira puama is an important ingredient of “catuama”, a medicinal poly-herbal combination used in South America, also composed of guaraná (Paullinia cupana), ginger (Zingiber officinale), and Trichilia catigua (Quattrocchi, 2012). One of the main active ingredients in muira puama is an alkaloid known as muirapuamine (Lorenzi and Matos, 2008).

Always practice enthusiastic consent: If you’re not sure whether your partner is into it, always ask! Where does arousal fit into the stages of sexual response? According to the United Kingdom’s National Health Services (NHS), researchers have identified four stages of sexual response — that is, the stages your body and mind goes through before, during, and after sex. Arousal falls into the first stage of the sexual response cycle. The sexual excitement stage — also known as the arousal stage — involves a range of physiological changes in the body. Most of these functions prepare the body for vaginal intercourse. For example, your vagina becomes more wet because the glands produce lubricating fluids. Your clitoris and vulva swell up as your blood vessels dilate. Your nipples might become more sensitive to touch, too.

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Ketamine causes what doctors call a “dissociative experience” and what most anyone else would call a “trip.” That’s how it became a club drug, called K, Special K, Super K, and Vitamin K among others. Partiers inject it, put it in drinks, snort it, or add it to joints or cigarettes. “Ketamine can produce feelings of unreality; visual and sensory distortions; a distorted feeling about one’s body; temporary unusual thoughts and beliefs; and a euphoria or a buzz,” says John Krystal, MD, chief of psychiatry at Yale-New Haven Hospital and Yale School of Medicine in Connecticut, where he is a leader in studying ketamine’s antidepressant effects.

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On its own, 500mg paracetamol has a success rate of around 43% meaning it only helps around 4 out of 10 people. In fact, researchers have found that, for every 3.5 people taking it, only one would experience good pain relief. Oddly, there is no evidence that higher doses (600mg to 1g) are more effective – in fact, they appear to be less effective than the 500mg dose! Products that combine paracetamol with ibuprofen work in up to 70% people, however, as mentioned above. A study published in the British Medical Journal, which looked at the results from 13 clinical trials, concluded that paracetamol is not effective for reducing back pain, and that it provides only minimal, short-term benefit for people with osteoarthritis of the hip or knee. The most likely explanation is that these conditions are associated with low-grade inflammation, and paracetamol lacks any anti-inflammatory action.

Tramadol should also be used cautiously in patients with impaired respiratory function, e.g. asthma, chronic obstructive pulmonary disease and sleep apnoea, and in patients with hypotension, shock, impaired consciousness or obstructive bowel disorders.5 If tramadol is prescribed to a patient taking warfarin, close monitoring of INR levels is recommended due to an increased risk of bleeding, particularly during the first week of treatment. Tramadol is contraindicated in children aged under two years due to the limited amount of safety and efficacy data.7 Liquid tramadol is sometimes given to children in a secondary care setting for post-operative pain; care is required to avoid over-dose as two strengths are available, i.e. 10 mg/mL and 100 mg/mL, however, these formulations are not subsidised for use in the community.

We asked parents to rate how helpful each medication was in the following areas: academic performance, behavior at school, behavior at home, self-esteem, and social relationships. Both amphetamines and methylphenidates were equally likely to be helpful in all areas with the exception of behavior at school, where amphetamines were rated as slightly more helpful. Although we don’t have enough cases of children taking “second line” medications (e.g. Straterra) to report specific findings, the data we have indicates that they were generally less likely to be “very helpful” than amphetamines or methylphenidates in the areas we asked about. If a child is struggling in the areas of self-esteem and relationships, and medication is not helpful, it might be useful to have him or her see a clinical psychologist or other mental-health professional.

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Ketamine got its start in Belgium in the 1960s as an anesthesia medicine for animals. The FDA approved it as an anesthetic for people in 1970. It was used in treating injured soldiers on the battlefields in the Vietnam War. Emergency responders may give it to an agitated patient who, for example, they have rescued from a suicide attempt. That’s how Ken Stewart, MD, says doctors began to realize that the drug had powerful effects against depression and suicidal thoughts.

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Dihydrocodeine is an opiate pain killer, similar to codeine, but more powerful. Dihydrocodeine is usually reserved to treat acute moderate pain which has not responded to paracetamol, ibuprofen or aspirin alone. It can be used to treat acute, moderate headache, migraine, period pains, dental pain, pain associated with cough, muscle pain and back ache. Dose: Depends on the formulation and how much paracetamol is also present. See instructions provided with each product. Dihydrocodeine is a more powerful version of codeine which is suitable for more severe pain. Until recently, it was only available on prescription. A formulation that combines dihydrocodeine with paracetamol is now available from pharmacies, but its use is carefully monitored as it has a potential for addiction.

Patients who have been taking an opioid for a short period of time for acute pain, e.g. one to two weeks, can usually stop it abruptly without the need for tapering the dose. However, a slower withdrawal may be considered for patients who have been taking frequent, higher doses.11 There is no specific guidance for a structured tapering regimen for short-term use of tramadol, but a pragmatic approach would be to reduce the dose by 25–50% each day. Ensure that when tramadol is withdrawn (either abruptly or tapered), analgesic cover is provided by concurrent use of paracetamol or a NSAID, until the pain is manageable without pharmacological treatment.

Overall, physicians did a decent job of screening before prescribing medication. Eighty-five percent of the children we surveyed received some sort of screening, and 76 percent were given a general medical exam. But only 52 percent had their blood pressure tested, 43 percent had blood tests done, and 22 percent were given an ECG/EKG exam for heart conditions. “Blood pressure should be measured, since medications that treat ADHD sometimes cause a slight increase in blood pressure,” says Michael L. Goldstein, M.D. It should be checked before starting medication, and at least once while the child is taking medication. And even though 85 percent of the children were screened before starting medication, 15 percent did not receive any type of screening. A parent should always request basic screening of their child before starting medication for ADHD.

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The most effective strategy for treating ADHD consists of more than one approach. There is some evidence that the combination of behavioral therapy with medication can work better than drugs alone for some children. But behavior therapy alone does not work for all children, especially those who have severe symptoms. As with most disorders for which multiple medications are available, there are no definitive comparison studies to show which ones work best in specific circumstances, according to Michael L. Goldstein, M.D., a child neurologist with Western Neurological Associates in Salt Lake City, and a former vice president of the American Academy of Neurology.

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Foraminotomy. In this procedure, the surgeon enlarges the bony hole where a nerve root exits the spinal canal to prevent bulging disks or joints thickened with age from pressing on the nerve. Nucleoplasty, also called plasma disk decompression. This laser surgery uses radiofrequency energy to treat people with low back pain associated with a mildly herniated disk. The surgeon inserts a needle into the disk. A plasma laser device is then inserted into the needle and the tip is heated, creating a field that vaporizes the tissue in the disk, reducing its size and relieving pressure on the nerves.

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